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A novel screening strategy of anti-SARS-CoV-2 drugs via blocking interaction between spike RBD and ACE2

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Glutathione peroxidase 4 (GPX4) utilizes reduced GSH to convert lipid hydroperoxides to lipid alcohols via oxidizing GSH to oxidized glutathione (GSSG), thereby preventing the lipid peroxidation of the cell membrane and inhibiting ferroptosis (6)